So what's the real reason behind grumpiness in gluten sensitive people?

The toxic component of the gluten is a protein called gliadin. Your immune system is constantly defending your body against attack – from bugs and from allergens. Unfortunately, gluten/gliadin is a strong allergen.

Thus, your body attacks gliadin by using a weapon called “antibodies”. These antibodies can repel gliadin. However, the outcome of this immune fight (against gliadin) is the production of antibodies that are specifically targeted towards gliadin: these are called “anti-gliadin antibodies”, or shortened to “gliadin antibodies”. It probably makes you ill through upsetting your body’s nervous system.

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